Cellular Microenvironment in Human Pathologies

Cellular Microenvironment in Human Pathologies

1 Department of Surgical and Morphological Sciences, University of Insubria, 21100 Varese, Italy 2 Department of Gynecology and Obstetrics, Münster University Hospital, 48149 Münster, Germany 3 Instituto de Bioquı́mica Médica and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro (UFRJ), 21941-590 Rio de Janeiro, RJ, Brazil 4Department of Chemistry, University ...

Microarraying the cellular microenvironment

The in vivo stem cell microenvironment or niche is composed of an intricate blend of extracellular matrix proteins, soluble protein factors, immobilized protein factors, proteoglycans, small molecule signals, in some cases mineralized tissue, and numerous adjacent cell types, all of which likely vary in space and time. In concert, these many components present the cells with an ‘array’ of bioch...

Patterning the cellular microenvironment.

Mitochondrial dysfunction in human pathologies.

The integrity of mitochondrial function is fundamental to cell life. The cell demands for mitochondria and their complex integration into cell biology, extends far beyond the provision of ATP. It follows that disturbances of mitochondrial function lead to disruption of cell function, expressed as disease or even death. Mitochondria are major producers of free radical species and also possibly o...

The Use of Cellular Technologies in Treatment of Liver Pathologies

Cell techniques find increasing application in modern clinical practice. The II and III phases of clinical trials are already under way for various cellular products used for the restoration of the functions of the cornea, larynx, skin, etc. However, the obtainment of functional cell types specific to different organs and tissues still remains a subject of laboratory research. Liver is one of t...